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KMID : 0931320070070010008
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대한상부위장관.헬리코박터학회지
2007 Volume.7 No. 1 p.8 ~ p.12
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Long-term Follow-up of Extra-gastric MALT Lymphoma: Single Center Study of 59 Cases
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Chung Su-Jin
Kim Sang-Gyun
Kim Chul-Woo
Kim Joo-Sung
Jung Hyun-Chae
Song In-Sung
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Abstract
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Background/Aims: We aimed to evaluate the clinicopathologic characteristics and the long-term outcome of patients with extra-gastric MALT lymphoma in respect to various treatment modalities.
Methods: We retrospectively studied 59 patients (29 males and 30 females) aged 19 to 79 years who had extra-gastric MALT lymphoma that were diagnosed at the Seoul National University Hospital between January 1996 and January 2006.
Results: Commonly involved sites were ocular adnexa (62.7%), lung (10.2%), and intestine (8.5%). Histopathologically, low to high grade ratio was 54:5. Among 48 patients who were staged, 30 (62.5%) had localized disease (stage IE or IIE) and 18 (37.5%) showed stage IV. Bone marrow involvement was observed in 3 cases. In localized-stage, complete remission (CR) was achieved in 90.0% (27/30). Among eighteen patients with stage IV, CR was obtained in 15 (83.3%) and 2 (11.1%) showed progression. The duration of median follow-up was 44 months and 11 patients with CR relapsed after 12 to 104 months. The estimated 5-year survival rate was 85.0%.
Conclusions: Although we found that the tendency to progress or relapse seemed to be more frequent in extra-gastric MALT lymphomas than gastric MALT lymphomas, majority of our cases had low-grade, good treatment response and good long-term prognosis. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2007;7:8-12)
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KEYWORD
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Extra-gastric mucosa-associated lymphoid tissue (MALT) lymphoma
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